Pandora's box

Pandora's box is a block that spawns in structures in Hades. It appears as an ordinary, benign chest, but when opened, will give to the player, practically every negative status effect. This will remove at least half of said player's health.

Mythological background
According to Greek mythology, Prometheus made the first man, but to do so, he stole fire from the gods, which greatly angered Zeus. Zeus punished mankind by creating the first woman, Pandora, who also brought with her a box which contained every horrible thing in the world. Pandora's curiosity eventually led her to open the box, which promptly doomed humanity to sin and misery.